A prior radiation therapy oncology group rtog clinical trial in anaplastic oligodendroglioma suggested a progressionfree survival. Pragmatic phase iii randomized trial of proton vs photon therapy for patients with nonmetastatic breast cancer receiving comprehensive nodal radiation. October 3, 2016 informed consent form pdf october 3, 2016 more information. A phase iii trial of accelerated whole breast irradiation. Radiation therapy with or without chemotherapy in treating. It is intended to be used only in conjunction with institutionspecific irb approval for study entry.
Sep 10, 2014 issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. A phase ii trial to evaluate hdr brachytherapy as monotherapy for stage i and ii breast carcinoma. Radiotherapy dose fractionation, third edition royal college of. A phase iii randomized study of high dose 3dcrtimrt vs. Oct 14, 2010 radiation therapy with or without chemotherapy in treating patients with highrisk malignant salivary gland tumors that have been removed by surgery.
A treatment planning comparison of contemporary photonbased. This may be contoured with autosegmentation with manual verification. Radiotherapy convert trial has compared the internationally accepted. This is an ascii program runs in a winterm or xterm window with a keyboard interface and commands, in windows a command prompt window and is invoked with the flag d followed by the directory where the rtog files are for the particular patient. Intermediate risk prostate cancer may be well controlled with brachytherapy alone initial report of large nrg oncology rtog 0232 study demonstrates effectiveness of prostate brachytherapy as a standalone modality for progression free survival boston, september 26, 2016 for men with intermediate risk prostate cancer, radiation treatment. Calgb 30610 rtog 0538 limited small cell 45 gy bid 3 weeks 61. For rtog 3d qa center purposes, it should be the patients name or some other identifier which the submitting institution can use to identify the data set in question should. Rtog 1010 radiation therapy oncology group rtog 1010 a phase iii trial evaluating the addition of trastuzumab to trimodality treatment of her2overexpressing esophageal adenocarcinoma schema step 1 registration v her2 testing mandatory submission of tissue for her2 testing.
Radiotherapy oncology group rtog demonstrated improved colostomyfree survival. Recommendations for hypofractionated wholebreast irradiation. However, it should have the same value for all image files for the same patient in the exchange file set. This site will allow users to register a patient or enter case form data directly to a nrgrtog study twentyfour 24 hours a day, seven 7 days a week. It is not yet known whether chemotherapy and radiation therapy are more effective when given with or without additional. Figure 1 shows a schematic diagram of the mcgill rt. Rtog is a participant in national cancer institute research through nrg oncology. Rtog 0538calgb 30610 protocol student doctor network. Rtog 4 ulceration, bleeding, necrosis rarely seen rtog assessment tool and intervention rationales please can you ensure that all patients on discharge are given one weeks supply of the dressings they are on. A planning comparison of 7 irradiation options allowed in. The mcgill rt format, on the other hand, was developed to minimize redundant information and minimize the number of. Assessment observation effects of radiotherapy on skin cells rationale rtog 0 no visible. This project was supported by grants u10ca21661, u10ca180868, u10ca180822, u10ca37422, and u24ca180803 from the national cancer institute nci.
The rtog format was designed for exporting and importing patient plans and thus, there is no simple method for saving small changes. Pdf risks and benefits of reducing target volume margins in. In this study for highrisk pca gleason 89 or high psa half of us got 2 months of lupron plus casodex, followed by 8 weeks 40 days of rt plus lupron, followed 1 month later by 2 years of lupron and up to 6 cycles of docetaxel. The decision to add weekly cisplatin for these patients is at the treating physicians discretion. During a course of radiation temporary skin reactions are common and vary from mild erythema to brisk, moist desquamation. Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Documents provided by radiation therapy oncology group. As broadcast on june 2, rtog 1005, a phase iii trial of accelerated whole breast irradiation with hypofractionation plus concurrent boost versus standard. A radiotherapy comparative effectiveness radcomp consortium trial. A planning comparison of 7 irradiation options allowed in rtog 1005 for earlystage breast cancer. Dose volume constraints were taken from the rtog protocol 1005.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Dosimetry plans were generated for 15 representative patients with earlystage breast cancer esbc based on the protocolrequired dosevolume criteria for each of the following 7. Bevacizumab with or without radiation therapy in treating. For clinics following rtog 1005, ezfluence allows the user to boost coverage to lumpectomy. No other use or reproduction is authorized by rtog nor does rtog assume. Longterm results of rtog 0236 confirm good primary tumor control, positive fiveyear survival rates. The severity of skin toxicity is dependent on volume of tissue treated, total daily dose, fractionation, dose distribution, and certain individual factors. Radiation therapy oncology group rtog 0618 a phase ii trial of stereotactic body radiation therapy sbrt in the treatment of patients with operable stage iii nonsmall cell lung cancer study chairs 2409 principal investigatorradiation oncologyigrt robert d. We would like to thank the nrg oncology rtog staff including minhee won, kathryn okrent, sandrine geinoz, barbara kaiser, and denise manfredi for their outstanding work on this clinical trial. Hyperfractionated rt for t2 glottic cancer results in rtog 9512. This study compared the 7 treatment plan options in achieving the dosevolume criteria required by the radiation therapy oncology group rtog 1005 protocol. Pelvic irradiation with concurrent chemotherapy versus. Pdf this study investigates the potential benefits of planning target volume ptv. About 60 percent of the adults enrolled in clinical trials are women.
Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. Clinical trials open at rapid city regional hospital. Highdose cisplatin administered at 100 mgm 2 represents the standard systemic agent in the control arm of randomized clinical trials that have recently been reported or completed accrual. Rtog is funded by national cancer institute grant numbers. Many more patients are enrolled in clinical trials sponsored by other groups. Randomised trial of hyperfractionation versus conventional fractionation in t2 squamous cell carcinoma of the vocal cord rtog 9512 eortc 22992. Radiation oncologyrtog trials wikibooks, open books for. Clicking on the protocol number will provide access to the protocol specific web page which includes specific information including the protocol, study forms, and other study documents.
Any imrt or vmat plan can be easily converted to a 3d plan in a matter of seconds. A phase iii comparison of thoracic radiotherapy regimens in patients with limited small cell lung cancer also receiving cisplatin and etoposide. This protocol was designed and developed by the radiation therapy oncology group rtog of the american college of radiology acr. Phase iii randomized study of concurrent chemotherapy and. Pathologically histologically or cytologically proven diagnosis of squamous cell carcinoma including the histological. Radiation therapy oncology group rtog 0618 a phase ii. A prior radiation therapy oncology group rtog clinical trial in anaplastic oligodendroglioma suggested a. Go to top of page study description study design arms and interventions outcome measures eligibility criteria contacts and locations more information. Easily share your publications and get them in front of issuus. May 16, 2016 nrg oncology rtog 6 a randomized phase ii study of individualized combined modality therapy for stage iii nonsmall cell lung cancer nsclc. A planning comparison of 7 irradiation options allowed in rtog. Radiation therapy uses highenergy xrays to kill tumor cells. Chen gp, liu f, white j, vicini fa, freedman gm, arthur dw, li xa.
Rtog 0618 a phase ii trial of sbrt in the treatment of patients with operable stage iii nonsmall cell lung cancer rtog 08 seamless phase iii study of sbrt for early stage, centrally located, nonsmall cell lung cancer in medically operable patients rtog 0236 has something for everyone. The rtog foundation study pages are accessible to participating institutions via a username and password. This falls between the range of local control rates reported in other series of single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases, 38% for recurrent glioblastoma, and 8294% for brain metastases 11, 12, 18. A pilot study of hypofractionated external beam radiation and hdr brachytherapy for advanced prostate cancer. Pdf bladder phase iii rtog study 9906 of patients with muscleinvasive bladder cancer undergoing transurethral surgery, paclitaxel. Standard dose 3dcrtimrt in patients treated for localized prostate cancer objective. Radiation therapy oncology group rtog and eastern cooperative oncology group ecog with similar findings of improved 1year and median survivals of 60% and. No other use or reproduction is authorized by rtog nor does rtog assume any. Billing justification plans are no longer a hassle or a stress to clinical resources. Clinical trials southeast radiation oncology group, p.
Patients with the following pathology findings may be treated with pelvic radiation with or without weekly cisplatin at the treating physicians discretion. Therefore, manual pareto optimization remains the best method to obtain. Implementation of radiosurgery and sbrt requires a. Clinical trials system american college of radiology. This site will allow users to register a patient or enter case form data directly to a nrg rtog study twentyfour 24 hours a day, seven 7 days a week. Stereotactic body radiation therapy for medically inoperable earlystage lung cancer patients stereotactic body radiation therapy sbrt stopped the growth of cancer at its original site in the lung for three years among nearly 98 percent of patients with early nonsmall cell lung cancer nsclc who are unable to have the cancer surgically removed, according to an. Nrg oncology rtog 6 a randomized phase ii study of. Lung, breast, prostate and colon cancers have the highest number of clinical trials dedicated to them more than 40 percent of the total number of trials.
Preliminary results of a phase ii study of a temozolomide tmz and radiotherapy rt in high risk low grade gliomas lggs find. Listing a study does not mean it has been evaluated by the u. Rtog 1016 phase iii trial of radiotherapy plus cetuximab. Rtog 1005, a phase iii trial of accelerated whole breast irradiation with hypofractionation plus concurrent boost versus standard whole breast irradiation plus sequential boost for earlystage breast cancer, will close to accrual on friday, june 20 th, as it will have met its accrual goal. A planning comparison of seven irradiation options allowed in. If you would like to utilize this site to register a patient and have not been assigned a login name and password from nrgrtog headquarters, please access the password. Rtog 1008 radiation therapy oncology group rtog 1008 a randomized phase ii study of adjuvant concurrent radiation and chemotherapy versus radiation alone in resected highrisk malignant salivary gland tumors study chairs 22712 coprincipal investigatormedical oncology pathology cochair cristina rodriguez, md adel elnaggar, m. Oct 21, 2016 we would like to thank the nrg oncology rtog staff including minhee won, kathryn okrent, sandrine geinoz, barbara kaiser, and denise manfredi for their outstanding work on this clinical trial. One of the prognostic variables associated with a significantly increased. If you would like to utilize this site to register a patient and have not been assigned a login name and password from nrg rtog headquarters, please access the password. Nov 21, 2012 documents provided by radiation therapy oncology group. Clinical trials at cdrp sites national cancer institute.
809 464 792 800 559 1374 338 307 1204 250 686 849 176 615 453 1191 906 874 1390 1175 543 1554 284 186 1109 913 574 501 313 806 231 1204 561 257